CIITA promoter polymorphism impairs monocytes HLA-DR expression in patients with septic shock

CIITA promoter polymorphism impairs monocytes HLA-DR expression in patients with septic shock

Summary: Low monocyte (m)HLA-DR expression is associated with mortality in sepsis. G-286A∗rs3087456 polymorphism in promoter III of HLA class II transactivator (CIITA), the master regulator of HLA, has been associated with autoimmune diseases but its role in sepsis has never been demonstrated. In 20...

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Bibliographic Details
Main Authors: Jordi Miatello, Anne-Claire Lukaszewicz, Michael J. Carter, Valérie Faivre, Stéphane Hua, Kim Z. Martinet, Christine Bourgeois, Lluis Quintana-Murci, Didier Payen, Michele Boniotto, Pierre Tissières
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:iScience
Subjects:
Health sciences
Genetics
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222015632

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222015632

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