Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures.

The importance of cholesterol and “oxysterols” in the regulation of cholesterol 7 alpha-hydroxylase is not clear. Previous in vivo studies suggest that cholesterol may up-regulate cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis, but these studies are open to quest...

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Bibliographic Details
Main Authors: K.C. Doerner, E.C. Gurley, Z.R. Vlahcevic, P.B. Hylemon
Format: Article
Language:English
Published: Elsevier 1995-06-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520411253