The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity

The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity

Fusion-negative rhabdomyosarcoma (FN-RMS) is molecularly heterogeneous with few universal alterations except for Phosphatase and tensin homolog (PTEN) promoter hypermethylation. We demonstrate that losing Pten in FN-RMS engages an aberrant transcriptional program key in tumor maintenance and cell id...

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Bibliographic Details
Main Authors: Casey G. Langdon, Mark E. Hatley
Format: Article
Language:English
Published: Taylor & Francis Group 2021-11-01
Series:Molecular & Cellular Oncology
Subjects:
rhabdomyosarcoma; pten; pax7; dbx1; leiomyosarcoma; mouse models of cancer; core regulatory circuits; sarcoma ;pediatric cancer; cancer and development
Online Access:http://dx.doi.org/10.1080/23723556.2021.2002120

Internet

http://dx.doi.org/10.1080/23723556.2021.2002120

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