Nkx2.8 promotes chemosensitivity in bladder urothelial carcinoma via transcriptional repression of MDR1

Nkx2.8 promotes chemosensitivity in bladder urothelial carcinoma via transcriptional repression of MDR1

Abstract Multidrug resistance gene 1 (MDR1), a key factor contributing to drug insensitivity, has been associated with treatment failure and poor prognoses in various cancers, including bladder urothelial carcinoma (UC). Here we show that positive Nkx2.8 expression was associated with better prognos...

Full description

Bibliographic Details
Main Authors: Zhaohui Zhou, Longbin Xiong, Zeshen Wu, Lijuan Jiang, Yonghong Li, Zhiyong Li, Yulu Peng, Kang Ning, Xiangpeng Zou, Zefu Liu, Jun Wang, Zhen Li, Fangjian Zhou, Zhuowei Liu, Zhiling Zhang, Chunping Yu
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04947-x

Internet

https://doi.org/10.1038/s41419-022-04947-x

Similar Items