Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia

Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia

1α,25-Dihydroxyvitamin D3 [1,25(OH)2D3], a vitamin D receptor (VDR) ligand, regulates calcium homeostasis and also exhibits noncalcemic actions on immunity and cell differentiation. In addition to disorders of bone and calcium metabolism, VDR ligands are potential therapeutic agents in the treatment...

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Bibliographic Details
Main Authors: Michiyasu Ishizawa, Manabu Matsunawa, Ryutaro Adachi, Shigeyuki Uno, Kazumasa Ikeda, Hiroyuki Masuno, Masato Shimizu, Ken-ichi Iwasaki, Sachiko Yamada, Makoto Makishima
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Journal of Lipid Research
Subjects:
nuclear receptor
intestine
leukemia
calcium
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520423892

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http://www.sciencedirect.com/science/article/pii/S0022227520423892

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