Development of a Novel PET Tracer [18F]AlF-NOTA-C6 Targeting MMP2 for Tumor Imaging.

Development of a Novel PET Tracer [18F]AlF-NOTA-C6 Targeting MMP2 for Tumor Imaging.

The overexpression of gelatinases, that is, matrix metalloproteinase MMP2 and MMP9, has been associated with tumor progression, invasion, and metastasis. To image MMP2 in tumors, we developed a novel ligand termed [18F]AlF-NOTA-C6, with consideration that: c(KAHWGFTLD)NH2 (herein, C6) is a selective...

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Bibliographic Details
Main Authors: Qinghua Liu, Donghui Pan, Chao Cheng, Dazhi Zhang, Anyu Zhang, Lizhen Wang, Hongdie Jiang, Tao Wang, Hongrui Liu, Yuping Xu, Runlin Yang, Fei Chen, Min Yang, Changjing Zuo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4634933?pdf=render

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http://europepmc.org/articles/PMC4634933?pdf=render

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