Screening of Scaffolds for the Design of G-Quadruplex Ligands

In the last decade, progress has been made in G-quadruplex (G4) ligands development, but for most compounds, the ligand binding mode is speculative or based on low resolution methods, with its discovery based on structure-based approaches. Herein, we report the synthesis of small (MW < 400 Da) he...

Full description

Bibliographic Details
Main Authors: Joana Figueiredo, David Peitinho, Maria Paula Cabral Campello, Maria Cristina Oliveira, António Paulo, Jean-Louis Mergny, Carla Cruz
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Applied Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3417/12/4/2170