New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies

New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies

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Fifteen quinazoline derivatives were designed and synthesized as DNA intercalators. The cytotoxicity of the designed members was assessed against HCT-116 and HepG2 cancer cell lines. In addition, the topoisomerase II (Topo II) inhibitory effect was assessed. Compound 16 was the most cytotoxic and To...

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Bibliographic Details
Main Authors: Ahmed A. Gaber, Mohamed Sobhy, Abdallah Turky, Wagdy M. Eldehna, Samiha A. El-Sebaey, Souad A. El-Metwally, Abeer M. El-Naggar, Ibrahim M. Ibrahim, Eslam B. Elkaeed, Ahmed M. Metwaly, Ibrahim H. Eissa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886266/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886266/?tool=EBI

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