Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency

Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency

Innate inflammatory responses are crucial for induction and regulation of T cell and antibody responses. Mast cell (MC)-deficient Kit mutant mice showed impaired adaptive immunity, suggesting that MCs provide essential adjuvant activities, and pharmacological MC activation was proposed as a new adju...

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Bibliographic Details
Main Authors: Nadja Schubert, Katharina Lisenko, Christian Auerbach, Anke Weitzmann, Shanawaz Mohammed Ghouse, Lina Muhandes, Christa Haase, Tobias Häring, Livia Schulze, David Voehringer, Florian Gunzer, Werner Müller, Thorsten B. Feyerabend, Hans-Reimer Rodewald, Anne Dudeck, Axel Roers
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
mast cells
adaptive immune responses
vaccination
adjuvant
compound 48/80
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01870/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01870/full

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