Analgesic Efficacy of a Combination of Fentanyl and a Japanese Herbal Medicine “<i>Yokukansan</i>” in Rats with Acute Inflammatory Pain

Analgesic Efficacy of a Combination of Fentanyl and a Japanese Herbal Medicine “<i>Yokukansan</i>” in Rats with Acute Inflammatory Pain

<b>Background:</b> Fentanyl can induce acute opioid tolerance and postoperative hyperalgesia when administered at a single high dose; thus, this study examined the analgesic efficacy of a combination of fentanyl and <i>Yokukansan</i> (YKS). <b>Methods:</b> Rats we...

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Bibliographic Details
Main Authors: Yuko Akanuma, Mami Kato, Yasunori Takayama, Hideshi Ikemoto, Naoki Adachi, Yusuke Ohashi, Wakako Yogi, Takayuki Okumo, Mana Tsukada, Masataka Sunagawa
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Medicines
Subjects:
<i>Yokukansan</i>
fentanyl
transient receptor potential ankyrin 1 (TRPA1) channel
phosphorylated extracellular signal-regulated kinase (pERK)
whole-cell patch-clamp recording
herbal medicine
Online Access:https://www.mdpi.com/2305-6320/7/12/75

Internet

https://www.mdpi.com/2305-6320/7/12/75

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