Investigation of two metabolic engineering approaches for (R,R)-2,3-butanediol production from glycerol in Bacillus subtilis

Investigation of two metabolic engineering approaches for (R,R)-2,3-butanediol production from glycerol in Bacillus subtilis

Abstract Background Flux Balance Analysis (FBA) is a well-known bioinformatics tool for metabolic engineering design. Previously, we have successfully used single-level FBA to design metabolic fluxes in Bacillus subtilis to enhance (R,R)-2,3-butanediol (2,3-BD) production from glycerol. OptKnock is...

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Bibliographic Details
Main Authors: Nunthaphan Vikromvarasiri, Shuhei Noda, Tomokazu Shirai, Akihiko Kondo
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Biological Engineering
Subjects:
Glycerol
2,3-Butanediol
Bacillus subtilis
Flux balance analysis
OptKnock
Genome-scale metabolic model
Online Access:https://doi.org/10.1186/s13036-022-00320-w

Internet

https://doi.org/10.1186/s13036-022-00320-w

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