Investigation of two metabolic engineering approaches for (R,R)-2,3-butanediol production from glycerol in Bacillus subtilis

Investigation of two metabolic engineering approaches for (R,R)-2,3-butanediol production from glycerol in Bacillus subtilis

Abstract Background Flux Balance Analysis (FBA) is a well-known bioinformatics tool for metabolic engineering design. Previously, we have successfully used single-level FBA to design metabolic fluxes in Bacillus subtilis to enhance (R,R)-2,3-butanediol (2,3-BD) production from glycerol. OptKnock is...

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Bibliographic Details
Main Authors:	Nunthaphan Vikromvarasiri, Shuhei Noda, Tomokazu Shirai, Akihiko Kondo
Format:	Article
Language:	English
Published:	BMC 2023-01-01
Series:	Journal of Biological Engineering
Subjects:	Glycerol 2,3-Butanediol Bacillus subtilis Flux balance analysis OptKnock Genome-scale metabolic model
Online Access:	https://doi.org/10.1186/s13036-022-00320-w

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