Poly(ADP-ribose) polymerase 1 searches DNA via a ‘monkey bar’ mechanism
Poly(ADP-ribose) polymerase 1 (PARP1) is both a first responder to DNA damage and a chromatin architectural protein. How PARP1 rapidly finds DNA damage sites in the context of a nucleus filled with undamaged DNA, to which it also binds, is an unresolved question. Here, we show that PARP1 association...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/37818 |