Bone marrow mesenchymal stem cells promote remyelination in spinal cord by driving oligodendrocyte progenitor cell differentiation via TNFα/RelB-Hes1 pathway: a rat model study of 2,5-hexanedione-induced neurotoxicity

Bone marrow mesenchymal stem cells promote remyelination in spinal cord by driving oligodendrocyte progenitor cell differentiation via TNFα/RelB-Hes1 pathway: a rat model study of 2,5-hexanedione-induced neurotoxicity

Abstract Background N-hexane, with its metabolite 2,5-hexanedine (HD), is an industrial hazardous material. Chronic hexane exposure causes segmental demyelination in the peripheral nerves, and high-dose intoxication may also affect central nervous system. Demyelinating conditions are difficult to tr...

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Bibliographic Details
Main Authors: Shuangyue Li, Huai Guan, Yan Zhang, Sheng Li, Kaixin Li, Shuhai Hu, Enjun Zuo, Cong Zhang, Xin Zhang, Guanyu Gong, Ruoyu Wang, Fengyuan Piao
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Stem Cell Research & Therapy
Subjects:
Bone marrow-mesenchymal stem cells
2,5-Hexanedione
Demyelination
Remyelination
Oligodendrocyte precursor cells
Notch1
Online Access:https://doi.org/10.1186/s13287-021-02518-z

Internet

https://doi.org/10.1186/s13287-021-02518-z

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