The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

The intrinsically disordered protein α-synuclein (aSN) is, in its fibrillated state, the main component of Lewy bodies—hallmarks of Parkinson’s disease. Additional Lewy body components include glycosaminoglycans, including heparan sulfate proteoglycans. In humans, heparan sulfate has, in an age-depe...

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Bibliographic Details
Main Authors: Line K. Skaanning, Angelo Santoro, Thomas Skamris, Jacob Hertz Martinsen, Anna Maria D’Ursi, Saskia Bucciarelli, Bente Vestergaard, Katrine Bugge, Annette Eva Langkilde, Birthe B. Kragelund
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Biomolecules
Subjects:
α-synuclein
heparin
fibrillation
NMR
binding
IDP
Online Access:https://www.mdpi.com/2218-273X/10/8/1192

Internet

https://www.mdpi.com/2218-273X/10/8/1192

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