Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.

Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.

OSBP-related protein 8 (ORP8) encoded by Osbpl8 is an endoplasmic reticulum sterol sensor implicated in cellular lipid metabolism. We generated an Osbpl8(-/-) (KO) C57Bl/6 mouse strain. Wild-type and Osbpl8KO animals at the age of 13-weeks were fed for 5 weeks either chow or high-fat diet, and their...

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Bibliographic Details
Main Authors: Olivier Béaslas, Jari Metso, Eija Nissilä, Pirkka-Pekka Laurila, Essi Kaiharju, Krishna Chaithanya Batchu, Leena Kaipiainen, Mikko I Mäyränpää, Daoguang Yan, Helena Gylling, Matti Jauhiainen, Vesa M Olkkonen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3598917?pdf=render

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http://europepmc.org/articles/PMC3598917?pdf=render

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