Incidence, clinical characteristics and prognosis of tumor lysis syndrome following B-cell maturation antigen-targeted chimeric antigen receptor-T cell therapy in relapsed/refractory multiple myeloma

Incidence, clinical characteristics and prognosis of tumor lysis syndrome following B-cell maturation antigen-targeted chimeric antigen receptor-T cell therapy in relapsed/refractory multiple myeloma

Background aimsB-cell maturation antigen (BCMA)-targeted chimeric antigen receptor-T cell (CAR-T) therapy is used for refractory or relapsed multiple myeloma (r/r MM). However, CAR-T-related tumor lysis syndrome (TLS) has been observed. We aimed to elucidate the incidence, clinical and laboratory ch...

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Bibliographic Details
Main Authors: Qiqi Zhang, Cheng Zu, Ruirui Jing, Youqin Feng, Yanlei Zhang, Mingming Zhang, Yuqi Lv, Jiazhen Cui, Linhui Zhou, Ye Meng, Linqin Wang, Zenan Cen, Alex H. Chang, Yongxian Hu, He Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
B-cell maturation antigen
chimeric antigen receptor-T
multiple myeloma
tumor lysis syndrome
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125357/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125357/full

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