A fetal fraction enrichment method reduces false negatives and increases test success rate of fetal chromosome aneuploidy detection in early pregnancy loss

A fetal fraction enrichment method reduces false negatives and increases test success rate of fetal chromosome aneuploidy detection in early pregnancy loss

Abstract Objective We and others have previously demonstrated that the size-selection enrichment method could remarkably improve fetal fraction (FF) in the early gestational age (GA, 12–13 weeks), suggesting that 9 or 10 weeks should not be used as a threshold for GA in size-selection noninvasive pr...

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Bibliographic Details
Main Authors: Longwei Qiao, Bin Zhang, Xiaojuan Wu, Chunhua Zhang, Ying Xue, Hui Tang, Haoyu Tang, Jingye Shi, Yuting Liang, Bin Yu, Ting Wang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Translational Medicine
Subjects:
Cell-free DNA
Fetal chromosomal aneuploidy
Fetal fraction enrichment method
Early pregnancy loss
Online Access:https://doi.org/10.1186/s12967-022-03555-9

Internet

https://doi.org/10.1186/s12967-022-03555-9

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