Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic β cells

Objective: Pancreatic β cell failure plays a central role in the development of type 2 diabetes (T2D). While the transcription factors shaping the β cell gene expression program have received much attention, the post-transcriptional controls that are activated in β cells during stress are largely un...

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Bibliographic Details
Main Authors: Austin L. Good, Matthew W. Haemmerle, Alexis U. Oguh, Nicolai M. Doliba, Doris A. Stoffers
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877819304703