A quantitative systems pharmacology model for certolizumab pegol treatment in moderate-to-severe psoriasis

A quantitative systems pharmacology model for certolizumab pegol treatment in moderate-to-severe psoriasis

BackgroundPsoriasis is a chronic immune-mediated inflammatory systemic disease with skin manifestations characterized by erythematous, scaly, itchy and/or painful plaques resulting from hyperproliferation of keratinocytes. Certolizumab pegol [CZP], a PEGylated antigen binding fragment of a humanized...

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Bibliographic Details
Main Authors: Pablo Coto-Segura, Cristina Segú-Vergés, Antonio Martorell, David Moreno-Ramírez, Guillem Jorba, Valentin Junet, Filippo Guerri, Xavier Daura, Baldomero Oliva, Carlos Cara, Olaya Suárez-Magdalena, Sonya Abraham, José Manuel Mas
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
psoriasis
anti-TNF
certolizumab pegol
mathematical modelling
virtual population
mechanism of action
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212981/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212981/full

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