Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives

Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives

Phenylketonuria (PKU) is a genetic disease caused by deficient activity of human phenylalanine hydroxylase (hPAH) that, when untreated, can lead to severe psychomotor impairment. Protein misfolding is recognized as the main underlying pathogenic mechanism of PKU. Therefore, the use of stabilizers of...

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Bibliographic Details
Main Authors: Raquel R. Lopes, Catarina S. Tomé, Roberto Russo, Roberta Paterna, João Leandro, Nuno R. Candeias, Lídia M. D. Gonçalves, Miguel Teixeira, Pedro M. F. Sousa, Rita C. Guedes, João B. Vicente, Pedro M. P. Gois, Paula Leandro
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomolecules
Subjects:
protein misfolding
drug discovery
inherited metabolic disorders
protein drug interactions
pharmacological chaperones
activity chaperones
Online Access:https://www.mdpi.com/2218-273X/11/3/462

Internet

https://www.mdpi.com/2218-273X/11/3/462

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