Engineering an anti-CD52 antibody for enhanced deamidation stability

Engineering an anti-CD52 antibody for enhanced deamidation stability

Deamidation evaluation and mitigation is an important aspect of therapeutic antibody developability assessment. We investigated the structure and function of the Asn-Gly deamidation in a human anti-CD52 IgG1 antibody light chain complementarity-determining region 1, and risk mitigation through prote...

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Bibliographic Details
Main Authors: Huawei Qiu, Ronnie Wei, Julie Jaworski, Ekaterina Boudanova, Heather Hughes, Scott VanPatten, Anders Lund, Jaime Day, Yanfeng Zhou, Tracey McSherry, Clark Q. Pan, Rebecca Sendak
Format: Article
Language:English
Published: Taylor & Francis Group 2019-10-01
Series:mAbs
Subjects:
Antibody engineering
deamidation
mutagenesis
developability
structure-function
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2019.1631117

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2019.1631117

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