Decoupling of mRNA and Protein Expression in Aging Brains Reveals the Age-Dependent Adaptation of Specific Gene Subsets

Decoupling of mRNA and Protein Expression in Aging Brains Reveals the Age-Dependent Adaptation of Specific Gene Subsets

During aging, changes in gene expression are associated with a decline in physical and cognitive abilities. Here, we investigate the connection between changes in mRNA and protein expression in the brain by comparing the transcriptome and proteome of the mouse cortex during aging. Our transcriptomic...

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Bibliographic Details
Main Authors: Inès Khatir, Marie A. Brunet, Anna Meller, Florent Amiot, Tushar Patel, Xavier Lapointe, Jessica Avila Lopez, Noé Guilloy, Anne Castonguay, Mohammed Amir Husain, Joannie St. Germain, François-Michel Boisvert, Mélanie Plourde, Xavier Roucou, Benoit Laurent
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
aging
brain
cortex
mRNA
transcriptome
protein
Online Access:https://www.mdpi.com/2073-4409/12/4/615

Internet

https://www.mdpi.com/2073-4409/12/4/615

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