Ratio Imaging of Enzyme Activity Using Dual Wavelength Optical Reporters

The design of near-infrared fluorescent (NIRF) probes that are activated by specific proteases has, for the first time, allowed enzyme activity to be imaged in vivo. In the current study, we report on a method of imaging enzyme activity using two fluorescent probes that, together, provide improved q...

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Bibliographic Details
Main Authors: Moritz F. Kircher, Lee Josephson, Ralph Weissleder
Format: Article
Language:English
Published: SAGE Publications 2002-04-01
Series:Molecular Imaging
Online Access:https://doi.org/10.1162/15353500200201124