Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial

Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial

Introduction Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroarte...

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Main Authors: Esperanca Sevene, Anifa Vala, Salésio Macuacua, Kassoum Kayentao, Issaka Sagara, Halidou Tinto, Clara Menendez, Raquel González, Umberto d'Alessandro, Hamadoun Diakite, Moussa Djimde, Hypolite Mavoko Muhindo, Mireia Piqueras, Petra Mens, Henk Schallig, Japhet Kabalu Tshiongo, Maminata Traore, Berenger Kabore, Edgard Diniba Dabira, Annette Erhart, Mohamed Keita, Thomas PC Dorlo
Format: Article
Language:English
Published: BMJ Publishing Group 2023-10-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/13/10/e065295.full

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https://bmjopen.bmj.com/content/13/10/e065295.full

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