The β3 Adrenergic Receptor Agonist BRL37344 Exacerbates Atrial Structural Remodeling Through iNOS Uncoupling in Canine Models of Atrial Fibrillation

Background/Aims: The role of the β3-adrenergic receptor (β3-AR) agonist BRL37344 in atrial fibrillation (AF) structural remodeling and the underlying mechanisms as a therapeutic target were investigated. Methods: Four groups of dogs were evaluated: sham, pacing, β3-AR agonist BRL37344 (β3-AGO), and...

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Bibliographic Details
Main Authors: Xiaobing Wang, Ruifeng Wang, Guangzhong Liu, Jingmei Dong, Guanqi Zhao, Jingpu Tian, Jiayu Sun, Xiuyue Jia, Lin Wei, Yuping Wang, Weimin Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Online Access:http://www.karger.com/Article/FullText/438647