The β3 Adrenergic Receptor Agonist BRL37344 Exacerbates Atrial Structural Remodeling Through iNOS Uncoupling in Canine Models of Atrial Fibrillation

The β3 Adrenergic Receptor Agonist BRL37344 Exacerbates Atrial Structural Remodeling Through iNOS Uncoupling in Canine Models of Atrial Fibrillation

Background/Aims: The role of the β3-adrenergic receptor (β3-AR) agonist BRL37344 in atrial fibrillation (AF) structural remodeling and the underlying mechanisms as a therapeutic target were investigated. Methods: Four groups of dogs were evaluated: sham, pacing, β3-AR agonist BRL37344 (β3-AGO), and...

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Bibliographic Details
Main Authors: Xiaobing Wang, Ruifeng Wang, Guangzhong Liu, Jingmei Dong, Guanqi Zhao, Jingpu Tian, Jiayu Sun, Xiuyue Jia, Lin Wei, Yuping Wang, Weimin Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Atrial fibrillation
β3-adrenergic receptor
Atrial structural remodeling
Oxidative stress
Nitric oxide synthase
Tetrahydrobiopterin
Online Access:http://www.karger.com/Article/FullText/438647

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