Primary explants of the postnatal thymus allow the expansion of clonogenic thymic epithelial cells that constitute thymospheres

Primary explants of the postnatal thymus allow the expansion of clonogenic thymic epithelial cells that constitute thymospheres

Abstract Background Thymic epithelial cells (TECs) are responsible for shaping the repertoires of T cells, where their postnatal regeneration depends on a subset of clonogenic TECs. Despite the implications for regenerative medicine, their cultivation and expansion remain challenging. Primary explan...

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Bibliographic Details
Main Authors: Juan M. Ocampo-Godinez, Jose L. Gonzalez-Quiroz, Hector Cote-Palafox, Elizabeth George, Jael A. Vergara-Lope Nuñez, Guillermo Villagomez-Olea, Febe C. Vazquez-Vazquez, Edgar O. Lopez-Villegas, Gloria Leon-Avila, Maria L. Dominguez-Lopez, Marco A. Alvarez-Perez
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Stem Cell Research & Therapy
Subjects:
Primary explant culture
Thymus regeneration
Clonogenic thymic epithelial cells
Adult stem cells
Regenerative medicine
Online Access:https://doi.org/10.1186/s13287-023-03529-8

Internet

https://doi.org/10.1186/s13287-023-03529-8

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