Accurate prediction of protein torsion angles using evolutionary signatures and recurrent neural network

Abstract The amino acid sequence of a protein contains all the necessary information to specify its shape, which dictates its biological activities. However, it is challenging and expensive to experimentally determine the three-dimensional structure of proteins. The backbone torsion angles play a cr...

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Bibliographic Details
Main Authors: Yong-Chang Xu, Tian-Jun ShangGuan, Xue-Ming Ding, Ngaam J. Cheung
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-00477-2