Nuclease-free precise genome editing corrects MECP2 mutations associated with Rett syndrome

Nuclease-free precise genome editing corrects MECP2 mutations associated with Rett syndrome

Rett syndrome is an acquired progressive neurodevelopmental disorder caused by de novo mutations in the X-linked MECP2 gene which encodes a pleiotropic protein that functions as a global transcriptional regulator and a chromatin modifier. Rett syndrome predominantly affects heterozygous females whil...

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Bibliographic Details
Main Authors: Swati Bijlani, Ka Ming Pang, Lakshmi V. Bugga, Sampath Rangasamy, Vinodh Narayanan, Saswati Chatterjee
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Genome Editing
Subjects:
genome editing
Rett syndrome
MeCP2
adeno-associated virus
homologous recombination
Online Access:https://www.frontiersin.org/articles/10.3389/fgeed.2024.1346781/full

Internet

https://www.frontiersin.org/articles/10.3389/fgeed.2024.1346781/full

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