Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts.

Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts.

In rodents, in utero exposure to exogenous estrogens including diethylstilboestrol (DES) results in major suppression of steroidogenesis in fetal testes. Whether similar effects occur in the human fetal testis is equivocal. Based on the results of the rodent studies, we hypothesised that exposure of...

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Bibliographic Details
Main Authors: Rod T Mitchell, Richard M Sharpe, Richard A Anderson, Chris McKinnell, Sheila Macpherson, Lee B Smith, W Hamish B Wallace, Christopher J H Kelnar, Sander van den Driesche
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3631175?pdf=render

Internet

http://europepmc.org/articles/PMC3631175?pdf=render

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