RNA-DNA hybrids prevent resection at dysfunctional telomeres

RNA-DNA hybrids prevent resection at dysfunctional telomeres

Summary: At critically short telomeres, stabilized TERRA RNA-DNA hybrids drive homology-directed repair (HDR) to delay replicative senescence. However, even at long- and intermediate-length telomeres, not subject to HDR, transient TERRA RNA-DNA hybrids form, suggestive of additional roles. We report...

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Bibliographic Details
Main Authors: Vanessa Borges Pires, Nina Lohner, Tina Wagner, Carolin B. Wagner, Maya Wilkens, Mona Hajikazemi, Katrin Paeschke, Falk Butter, Brian Luke
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723000888

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http://www.sciencedirect.com/science/article/pii/S2211124723000888

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