Acridine Based <i>N</i>-Acylhydrazone Derivatives as Potential Anticancer Agents: Synthesis, Characterization and ctDNA/HSA Spectroscopic Binding Properties

Acridine Based <i>N</i>-Acylhydrazone Derivatives as Potential Anticancer Agents: Synthesis, Characterization and ctDNA/HSA Spectroscopic Binding Properties

A series of novel acridine <i>N</i>-acylhydrazone derivatives have been synthesized as potential topoisomerase I/II inhibitors, and their binding (calf thymus DNA—ctDNA and human serum albumin—HSA) and biological activities as potential anticancer agents on proliferation of A549 and CCD-...

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Bibliographic Details
Main Authors: Mária Vilková, Monika Hudáčová, Nikola Palušeková, Rastislav Jendželovský, Miroslav Almáši, Tibor Béres, Peter Fedoročko, Mária Kožurková
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
acridine
benzohydrazide
ctDNA
HSA binding
spectroscopic study
Online Access:https://www.mdpi.com/1420-3049/27/9/2883

Internet

https://www.mdpi.com/1420-3049/27/9/2883

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