The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activity

The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activity

The binding of SARS-CoV-2 nucleocapsid (N) protein to both the 5′- and 3′-ends of genomic RNA has different implications arising from its binding to the central region during virion assembly. However, the mechanism underlying selective binding remains unknown. Herein, we performed the high-throughpu...

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Bibliographic Details
Main Authors: Shaorong Fan, Wenju Sun, Ligang Fan, Nan Wu, Wei Sun, Haiqian Ma, Siyuan Chen, Zitong Li, Yu Li, Jilin Zhang, Jian Yan
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
SARS-CoV-2
Nucleocapsid protein
RNA binding specificity
Coronavirus
Conserved
Virion assembly
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022004123

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http://www.sciencedirect.com/science/article/pii/S2001037022004123

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