Global PIEZO1 Gain-of-Function Mutation Causes Cardiac Hypertrophy and Fibrosis in Mice

Global PIEZO1 Gain-of-Function Mutation Causes Cardiac Hypertrophy and Fibrosis in Mice

PIEZO1 is a subunit of mechanically-activated, nonselective cation channels. Gain-of-function PIEZO1 mutations are associated with dehydrated hereditary stomatocytosis (DHS), a type of anaemia, due to abnormal red blood cell function. Here, we hypothesised additional effects on the heart. Consistent...

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Bibliographic Details
Main Authors: Fiona Bartoli, Elizabeth L. Evans, Nicola M. Blythe, Leander Stewart, Eulashini Chuntharpursat-Bon, Marjolaine Debant, Katie E. Musialowski, Laeticia Lichtenstein, Gregory Parsonage, T. Simon Futers, Neil A. Turner, David J. Beech
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
PIEZO1
mechanotransduction
heart
hypertrophy
fibrosis
fibroblasts
Online Access:https://www.mdpi.com/2073-4409/11/7/1199

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https://www.mdpi.com/2073-4409/11/7/1199

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