XLF/Cernunnos loss impairs mouse brain development by altering symmetric proliferative divisions of neural progenitors

XLF/Cernunnos loss impairs mouse brain development by altering symmetric proliferative divisions of neural progenitors

Summary: XLF/Cernunnos is a component of the ligation complex used in classical non-homologous end-joining (cNHEJ), a major DNA double-strand break (DSB) repair pathway. We report neurodevelopmental delays and significant behavioral alterations associated with microcephaly in Xlf−/− mice. This pheno...

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Bibliographic Details
Main Authors: Amandine Bery, Olivier Etienne, Laura Mouton, Sofiane Mokrani, Christine Granotier-Beckers, Laurent R. Gauthier, Justyne Feat-Vetel, Thierry Kortulewski, Elodie A. Pérès, Chantal Desmaze, Philippe Lestaveal, Vilma Barroca, Antony Laugeray, Fawzi Boumezbeur, Vincent Abramovski, Stéphane Mortaud, Arnaud Menuet, Denis Le Bihan, Jean-Pierre de Villartay, François D. Boussin
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Cell Reports
Subjects:
CP: Developmental biology
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723003534

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http://www.sciencedirect.com/science/article/pii/S2211124723003534

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