The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice
Brain computations rely on a proper balance between excitation and inhibition which progressively emerges during postnatal development in rodent. γ-Aminobutyric acid (GABA) neurotransmission supports inhibition in the adult brain but excites immature rodent neurons. Alterations in the timing of the...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/36726 |
| _version_ | 1811200771621912576 |
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| author | Camille Dumon Diabe Diabira Ilona Chudotvorova Francesca Bader Semra Sahin Jinwei Zhang Christophe Porcher Gary Wayman Igor Medina Jean-Luc Gaiarsa |
| author_facet | Camille Dumon Diabe Diabira Ilona Chudotvorova Francesca Bader Semra Sahin Jinwei Zhang Christophe Porcher Gary Wayman Igor Medina Jean-Luc Gaiarsa |
| author_sort | Camille Dumon |
| collection | DOAJ |
| description | Brain computations rely on a proper balance between excitation and inhibition which progressively emerges during postnatal development in rodent. γ-Aminobutyric acid (GABA) neurotransmission supports inhibition in the adult brain but excites immature rodent neurons. Alterations in the timing of the GABA switch contribute to neurological disorders, so unveiling the involved regulators may be a promising strategy for treatment. Here we show that the adipocyte hormone leptin sets the tempo for the emergence of GABAergic inhibition in the newborn rodent hippocampus. In the absence of leptin signaling, hippocampal neurons show an advanced emergence of GABAergic inhibition. Conversely, maternal obesity associated with hyperleptinemia delays the excitatory to inhibitory switch of GABA action in offspring. This study uncovers a developmental function of leptin that may be linked to the pathogenesis of neurological disorders and helps understanding how maternal environment can adversely impact offspring brain development. |
| first_indexed | 2024-04-12T02:09:16Z |
| format | Article |
| id | doaj.art-9333da0fecef43d18898c2947b25c273 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:09:16Z |
| publishDate | 2018-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-9333da0fecef43d18898c2947b25c2732022-12-22T03:52:27ZengeLife Sciences Publications LtdeLife2050-084X2018-08-01710.7554/eLife.36726The adipocyte hormone leptin sets the emergence of hippocampal inhibition in miceCamille Dumon0https://orcid.org/0000-0002-1625-3091Diabe Diabira1Ilona Chudotvorova2Francesca Bader3Semra Sahin4Jinwei Zhang5https://orcid.org/0000-0001-8683-509XChristophe Porcher6Gary Wayman7Igor Medina8https://orcid.org/0000-0001-6839-5414Jean-Luc Gaiarsa9https://orcid.org/0000-0001-7354-0559Aix-Marseille University UMR 1249, INSERM (Institut National de la Santé et de la Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de la Méditerranée), Marseille, FranceAix-Marseille University UMR 1249, INSERM (Institut National de la Santé et de la Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de la Méditerranée), Marseille, FranceAix-Marseille University UMR 1249, INSERM (Institut National de la Santé et de la Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de la Méditerranée), Marseille, FranceAix-Marseille University UMR 1249, INSERM (Institut National de la Santé et de la Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de la Méditerranée), Marseille, France; Plateforme Post-Génomique, INMED, Marseille, FranceProgram in Neuroscience, Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, United StatesInstitute of Biochemical and Clinical Sciences, Hatherly Laboratory, University of Exeter Medical School, Exeter, United KingdomAix-Marseille University UMR 1249, INSERM (Institut National de la Santé et de la Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de la Méditerranée), Marseille, FranceProgram in Neuroscience, Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, United StatesAix-Marseille University UMR 1249, INSERM (Institut National de la Santé et de la Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de la Méditerranée), Marseille, FranceAix-Marseille University UMR 1249, INSERM (Institut National de la Santé et de la Recherche Médicale) Unité 1249, INMED (Institut de Neurobiologie de la Méditerranée), Marseille, FranceBrain computations rely on a proper balance between excitation and inhibition which progressively emerges during postnatal development in rodent. γ-Aminobutyric acid (GABA) neurotransmission supports inhibition in the adult brain but excites immature rodent neurons. Alterations in the timing of the GABA switch contribute to neurological disorders, so unveiling the involved regulators may be a promising strategy for treatment. Here we show that the adipocyte hormone leptin sets the tempo for the emergence of GABAergic inhibition in the newborn rodent hippocampus. In the absence of leptin signaling, hippocampal neurons show an advanced emergence of GABAergic inhibition. Conversely, maternal obesity associated with hyperleptinemia delays the excitatory to inhibitory switch of GABA action in offspring. This study uncovers a developmental function of leptin that may be linked to the pathogenesis of neurological disorders and helps understanding how maternal environment can adversely impact offspring brain development.https://elifesciences.org/articles/36726hippocampuschloride homeostasismaternal obesityKCC2GABA |
| spellingShingle | Camille Dumon Diabe Diabira Ilona Chudotvorova Francesca Bader Semra Sahin Jinwei Zhang Christophe Porcher Gary Wayman Igor Medina Jean-Luc Gaiarsa The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice eLife hippocampus chloride homeostasis maternal obesity KCC2 GABA |
| title | The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice |
| title_full | The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice |
| title_fullStr | The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice |
| title_full_unstemmed | The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice |
| title_short | The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice |
| title_sort | adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice |
| topic | hippocampus chloride homeostasis maternal obesity KCC2 GABA |
| url | https://elifesciences.org/articles/36726 |
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