Vasoactive Intestinal Peptide Receptor, CRTH2, Antagonist Treatment Improves Eosinophil and Mast Cell-Mediated Esophageal Remodeling and Motility Dysfunction in Eosinophilic Esophagitis

Vasoactive Intestinal Peptide Receptor, CRTH2, Antagonist Treatment Improves Eosinophil and Mast Cell-Mediated Esophageal Remodeling and Motility Dysfunction in Eosinophilic Esophagitis

Background and Aims: Ultrasonography has shown that eosinophils accumulate in each segment of the esophageal mucosa in human EoE, ultimately promoting esophageal motility dysfunction; however, no mechanistic evidence explains how or why this accumulation occurs. Methods: Quantitative PCR, ELISA, flo...

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Bibliographic Details
Main Authors: Chandra Sekhar Yadavalli, Sathisha Upparahalli Venkateshaiah, Alok K. Verma, Chandrasekhar Kathera, Pearce S. Duncan, Michael Vaezi, Richard J. Paul, Anil Mishra
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
CRTH2
eosinophils
esophagus
EoE
mast cells
motility
Online Access:https://www.mdpi.com/2073-4409/13/4/295

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https://www.mdpi.com/2073-4409/13/4/295

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