Restoration of miR-193a expression is tumor-suppressive in MYC amplified Group 3 medulloblastoma

Restoration of miR-193a expression is tumor-suppressive in MYC amplified Group 3 medulloblastoma

Abstract Medulloblastoma, a highly malignant pediatric brain tumor, consists of four molecular subgroups, namely WNT, SHH, Group 3, and Group 4. The expression of miR-193a, a WNT subgroup-specific microRNA, was found to be induced by MYC, an oncogenic target of the canonical WNT signaling. MiR-193a...

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Bibliographic Details
Main Authors: Harish Shrikrishna Bharambe, Annada Joshi, Kedar Yogi, Sadaf Kazi, Neelam Vishwanath Shirsat
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Acta Neuropathologica Communications
Subjects:
MiR-193a
MYC
MAX
Medulloblastoma
Promoter methylation
Online Access:http://link.springer.com/article/10.1186/s40478-020-00942-5

Internet

http://link.springer.com/article/10.1186/s40478-020-00942-5

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