GILT Expression in Human Melanoma Cells Enhances Generation of Antigenic Peptides for HLA Class II-Mediated Immune Recognition

GILT Expression in Human Melanoma Cells Enhances Generation of Antigenic Peptides for HLA Class II-Mediated Immune Recognition

Melanoma is an aggressive skin cancer that has become increasingly prevalent in western populations. Current treatments such as surgery, chemotherapy, and high-dose radiation have had limited success, often failing to treat late stage, metastatic melanoma. Alternative strategies such as immunotherap...

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Bibliographic Details
Main Authors: Jessica D. Hathaway-Schrader, Duncan Norton, Katherine Hastings, Bently P. Doonan, Shaun Tompkins Fritz, Jennifer R. Bethard, Janice S. Blum, Azizul Haque
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
gamma-IFN-inducible lysosomal thiol-reductase (GILT)
melanoma
Ag presenting cells (APCs)
human leukocyte antigen (HLA) class II
cathepsins
CD4+ T cells
Online Access:https://www.mdpi.com/1422-0067/23/3/1066

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https://www.mdpi.com/1422-0067/23/3/1066

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