Population pharmacokinetics of buprenorphine and naloxone sublingual combination in Chinese healthy volunteers and patients with opioid use disorder: Model-based dose optimization

Population pharmacokinetics of buprenorphine and naloxone sublingual combination in Chinese healthy volunteers and patients with opioid use disorder: Model-based dose optimization

The sublingual combination of buprenorphine (BUP) and naloxone (NLX) is a new treatment option for opioid use disorder (OUD) and is effective in preventing drug abuse. This study aimed to explore rational dosing regimen for OUD patients in China via a model-based dose optimization approach. BUP, nor...

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Bibliographic Details
Main Authors: Meng Gu, Anning Li, Wenyao Mak, Fang Dong, Nuo Xu, Jingye Zhang, Yufei Shi, Nan Zheng, Zhijia Tang, Qingfeng He, Canjun Ruan, Wei Guo, Xiaoqiang Xiang, Chuanyue Wang, Bing Han, Xiao Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
buprenorphine + naloxone
sublingual
population pharmacokinetics
parent-metabolite model
opioid use disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1089862/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1089862/full

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