Third-generation rabies viral vectors allow nontoxic retrograde targeting of projection neurons with greatly increased efficiency
Summary: Rabies viral vectors have become important components of the systems neuroscience toolkit, allowing both direct retrograde targeting of projection neurons and monosynaptic tracing of inputs to defined postsynaptic populations, but the rapid cytotoxicity of first-generation (ΔG) vectors limi...
Main Authors: | Lei Jin, Heather A. Sullivan, Mulangma Zhu, Nicholas E. Lea, Thomas K. Lavin, Xin Fu, Makoto Matsuyama, YuanYuan Hou, Guoping Feng, Ian R. Wickersham |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-11-01
|
Series: | Cell Reports: Methods |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2667237523003156 |
Similar Items
-
Retrograde adenosine/A2A receptor signaling facilitates excitatory synaptic transmission and seizures
by: Kaoutsar Nasrallah, et al.
Published: (2024-07-01) -
Opposing retrograde and astrocyte-dependent endocannabinoid signaling mechanisms regulate lateral habenula synaptic transmission
by: Nathan D. Winters, et al.
Published: (2023-03-01) -
Aberrant serotonergic signaling contributes to the hyperexcitability of CA1 pyramidal neurons in a mouse model of Alzheimer’s disease
by: Jing Wang, et al.
Published: (2023-03-01) -
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes
by: Platon Megagiannis, et al.
Published: (2024-08-01) -
Distinct genetic and environmental origins of hierarchical cognitive abilities in adult humans
by: Shaohan Jiang, et al.
Published: (2024-04-01)