Human pluripotent stem cell-derived brain organoids as in vitro models for studying neural disorders and cancer
Abstract The sheer complexities of brain and resource limitation of human brain tissue greatly hamper our understanding of the brain disorders and cancers. Recently developed three-dimensional (3D) brain organoids (BOs) are self-organized and spontaneously differentiated from human pluripotent stem...
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-021-00617-1 |
| _version_ | 1818601828045029376 |
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| author | Juan Luo Peng Li |
| author_facet | Juan Luo Peng Li |
| author_sort | Juan Luo |
| collection | DOAJ |
| description | Abstract The sheer complexities of brain and resource limitation of human brain tissue greatly hamper our understanding of the brain disorders and cancers. Recently developed three-dimensional (3D) brain organoids (BOs) are self-organized and spontaneously differentiated from human pluripotent stem cells (hPSCs) in vitro, which exhibit similar features with cell type diversity, structural organization, and functional connectivity as the developing human brain. Based on these characteristics, hPSC-derived BOs (hPDBOs) provide new opportunities to recapitulate the complicated processes during brain development, neurodegenerative disorders, and brain cancers in vitro. In this review, we will provide an overview of existing BO models and summarize the applications of this technology in modeling the neural disorders and cancers. Furthermore, we will discuss the challenges associated with their use as in vitro models for disease modeling and the potential future direction. |
| first_indexed | 2024-12-16T12:57:35Z |
| format | Article |
| id | doaj.art-93402bcd17504cdaaff2e7f38b4d7b06 |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-12-16T12:57:35Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-93402bcd17504cdaaff2e7f38b4d7b062022-12-21T22:30:59ZengBMCCell & Bioscience2045-37012021-05-0111111710.1186/s13578-021-00617-1Human pluripotent stem cell-derived brain organoids as in vitro models for studying neural disorders and cancerJuan Luo0Peng Li1Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityAbstract The sheer complexities of brain and resource limitation of human brain tissue greatly hamper our understanding of the brain disorders and cancers. Recently developed three-dimensional (3D) brain organoids (BOs) are self-organized and spontaneously differentiated from human pluripotent stem cells (hPSCs) in vitro, which exhibit similar features with cell type diversity, structural organization, and functional connectivity as the developing human brain. Based on these characteristics, hPSC-derived BOs (hPDBOs) provide new opportunities to recapitulate the complicated processes during brain development, neurodegenerative disorders, and brain cancers in vitro. In this review, we will provide an overview of existing BO models and summarize the applications of this technology in modeling the neural disorders and cancers. Furthermore, we will discuss the challenges associated with their use as in vitro models for disease modeling and the potential future direction.https://doi.org/10.1186/s13578-021-00617-1Human pluripotent stem cellsBrain organoidsNeural disordersCancer |
| spellingShingle | Juan Luo Peng Li Human pluripotent stem cell-derived brain organoids as in vitro models for studying neural disorders and cancer Cell & Bioscience Human pluripotent stem cells Brain organoids Neural disorders Cancer |
| title | Human pluripotent stem cell-derived brain organoids as in vitro models for studying neural disorders and cancer |
| title_full | Human pluripotent stem cell-derived brain organoids as in vitro models for studying neural disorders and cancer |
| title_fullStr | Human pluripotent stem cell-derived brain organoids as in vitro models for studying neural disorders and cancer |
| title_full_unstemmed | Human pluripotent stem cell-derived brain organoids as in vitro models for studying neural disorders and cancer |
| title_short | Human pluripotent stem cell-derived brain organoids as in vitro models for studying neural disorders and cancer |
| title_sort | human pluripotent stem cell derived brain organoids as in vitro models for studying neural disorders and cancer |
| topic | Human pluripotent stem cells Brain organoids Neural disorders Cancer |
| url | https://doi.org/10.1186/s13578-021-00617-1 |
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