Preferential Regulation of Γ‐Secretase‐Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease

Preferential Regulation of Γ‐Secretase‐Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease

Abstract A hallmark of Alzheimer's disease (AD) is the senile plaque, which contains β‐amyloid peptides (Aβ). Ganglioside GM1 is the most common brain ganglioside. However, the mechanism of GM1 in modulating Aβ processing is rarely known. Aβ levels are detected by using Immunohistochemistry (IH...

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Bibliographic Details
Main Authors: Xiaotong Wang, Rui Zhou, Xiaqin Sun, Jun Li, Jinxin Wang, Weihua Yue, Lifang Wang, Hesheng Liu, Yigong Shi, Dai Zhang
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Advanced Science
Subjects:
Alzheimer's disease
conformation
ganglioside GM1
presenilin1
β‐amyloid protein
Online Access:https://doi.org/10.1002/advs.202303411

Internet

https://doi.org/10.1002/advs.202303411

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