Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome

Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome

A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) chemotherapy. However, the molecular composition and operation of the encoded ‘mycobacterial mutasome’ – minimally comprising DnaE2 polym...

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Bibliographic Details
Main Authors: Sophia Gessner, Zela Alexandria-Mae Martin, Michael A Reiche, Joana A Santos, Ryan Dinkele, Atondaho Ramudzuli, Neeraj Dhar, Timothy J de Wet, Saber Anoosheh, Dirk M Lang, Jesse Aaron, Teng-Leong Chew, Jennifer Herrmann, Rolf Müller, John D McKinney, Roger Woodgate, Valerie Mizrahi, Česlovas Venclovas, Meindert H Lamers, Digby F Warner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-08-01
Series:eLife
Subjects:
Mycobacterium tuberculosis
Mycobacterium smegmatis
induced mutagenesis
antibiotic resistance
anti-evolution
mutasome
Online Access:https://elifesciences.org/articles/75628

Internet

https://elifesciences.org/articles/75628

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