The impact of C216T and hot spot mutations of the TERT promoter on the clinicopathologic characteristics and S100A10 expression in papillary thyroid carcinoma: a comparative study

Abstract Objective The C216T mutation in the TERT promoter (TERTp) is a rarely reported genetic alteration in papillary thyroid carcinoma (PTC). Its clinical significance remains unclear. This study aimed to compare the impact of the C216T and hot spot mutations (C228T and C250T) of TERTp on the cli...

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Bibliographic Details
Main Authors: Ping Li, Chuqiang Huang, Xiaoling Liu, Huihui Gui, Jian Li
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Diagnostic Pathology
Subjects:
Online Access:https://doi.org/10.1186/s13000-025-01613-6