Memantine and Riluzole Exacerbate, Rather Than Ameliorate Behavioral Deficits Induced by 8-OH-DPAT Sensitization in a Spatial Task

Memantine and Riluzole Exacerbate, Rather Than Ameliorate Behavioral Deficits Induced by 8-OH-DPAT Sensitization in a Spatial Task

Chronic sensitization to serotonin 1A and 7 receptors agonist 8-OH-DPAT induces compulsive checking and perseverative behavior. As such, it has been used to model obsessive-compulsive disorder (OCD)-like behavior in mice and rats. In this study, we tested spatial learning in the 8-OH-DPAT model of O...

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Bibliographic Details
Main Authors: Martina Janikova, Karolina Mainerova, Iveta Vojtechova, Tomas Petrasek, Jan Svoboda, Ales Stuchlik
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biomolecules
Subjects:
obsessive-compulsive disorder
8-OH-DPAT
memantine
riluzole
spatial learning
memory
Online Access:https://www.mdpi.com/2218-273X/11/7/1007

Internet

https://www.mdpi.com/2218-273X/11/7/1007

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