Novel-Substituted Heterocyclic GABA Analogues. Enzymatic Activity against the GABA-AT Enzyme from Pseudomonas fluorescens and In Silico Molecular Modeling

Novel-Substituted Heterocyclic GABA Analogues. Enzymatic Activity against the GABA-AT Enzyme from Pseudomonas fluorescens and In Silico Molecular Modeling

γ-Aminobutyric acid (GABA) is the most important inhibitory neurotransmitter in the central nervous system, and a deficiency of GABA is associated with serious neurological disorders. Due to its low lipophilicity, there has been an intensive search for new molecules with increased lipophil...

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Bibliographic Details
Main Authors: Erika Tovar-Gudiño, Juan Alberto Guevara-Salazar, José Raúl Bahena-Herrera, José Guadalupe Trujillo-Ferrara, Zuleyma Martínez-Campos, Rodrigo Said Razo-Hernández, Ángel Santiago, Nina Pastor, Mario Fernández-Zertuche
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Molecules
Subjects:
heterocyclic GABA analogues
GABA-AT inhibitors
GABA-AT docking
molecular electrostatic potential
Online Access:http://www.mdpi.com/1420-3049/23/5/1128

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http://www.mdpi.com/1420-3049/23/5/1128

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