Unveiling the Role of Cholesterol in Subnanomolar Ouabain Rescue of Cortical Neurons from Calcium Overload Caused by Excitotoxic Insults

Unveiling the Role of Cholesterol in Subnanomolar Ouabain Rescue of Cortical Neurons from Calcium Overload Caused by Excitotoxic Insults

Na/K-ATPase maintains transmembrane ionic gradients and acts as a signal transducer when bound to endogenous cardiotonic steroids. At subnanomolar concentrations, ouabain induces neuroprotection against calcium overload and apoptosis of neurons during excitotoxic stress. Here, the role of lipid raft...

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Bibliographic Details
Main Authors: Dmitry A. Sibarov, Zoia D. Zhuravleva, Margarita A. Ilina, Sergei I. Boikov, Yulia D. Stepanenko, Tatiana V. Karelina, Sergei M. Antonov
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
NMDA receptor
neurons
Na/K-ATPase
cholesterol
calcium
Na/Ca exchanger
Online Access:https://www.mdpi.com/2073-4409/12/15/2011

Internet

https://www.mdpi.com/2073-4409/12/15/2011

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