Rutaecarpine, an Alkaloid from <i>Evodia rutaecarpa</i>, Can Prevent Platelet Activation in Humans and Reduce Microvascular Thrombosis in Mice: Crucial Role of the PI3K/Akt/GSK3β  Signal Axis through a Cyclic Nucleotides/VASP—Independent Mechanism

Rutaecarpine, an Alkaloid from <i>Evodia rutaecarpa</i>, Can Prevent Platelet Activation in Humans and Reduce Microvascular Thrombosis in Mice: Crucial Role of the PI3K/Akt/GSK3β  Signal Axis through a Cyclic Nucleotides/VASP—Independent Mechanism

The role of activated platelets in acute and chronic cardiovascular diseases (CVDs) is well established. Therefore, antiplatelet drugs significantly reduce the risk of severe CVDs. <i>Evodia rutaecarpa</i> (Wu-Chu-Yu) is a well-known Chinese medicine, and rutaecarpine (Rut) is a main bio...

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Bibliographic Details
Main Authors: Chun-Jen Huang, Wei-Chieh Huang, Wei-Ting Lin, Lan-Hsin Shu, Joen-Rong Sheu, Oanh-Thi Tran, Chih-Wei Hsia, Thanasekaran Jayakumar, Periyakali Saravana Bhavan, Cheng-Ying Hsieh, Chao-Chien Chang
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
cyclic nucleotide
human platelets
hydroxyl radical
rutaecarpine
MAPK
microvascular thrombosis
Online Access:https://www.mdpi.com/1422-0067/22/20/11109

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https://www.mdpi.com/1422-0067/22/20/11109

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